Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:7358641

Studies on D-tetrose metabolism. Crystallization and properties of D-erythrulose reductase from chicken liver.

Native chicken liver enzyme is a tetramer that reduces D-erythrulose to D-threitol, preferring NADPH over NADH.

"The enzyme was shown to catalyze the reduction of D-erythrulose to D-threitol with the concomitant oxidation of NAD(P)H to NAD(P)+, and was highly specific to D-erythrulose with an apparent Km of 0.38 mM"

PMID:9538249

D-erythrulose reductase can also reduce diacetyl: further purification and characterization of D-erythrulose reductase from chicken liver.

Chicken DER also reduces alpha-diketones such as diacetyl and is predominant in kidney and liver.

"it can catalyze reduction of not only D-erythrulose but also such diketones as diacetyl"

PMID:12200544

Cloning and sequence analysis of D-erythrulose reductase from chicken: its close structural relation to tetrameric carbonyl reductases.

cDNA cloning of chicken DER (246 aa), >60% identity to mouse tetrameric carbonyl reductase but with distinct substrate specificity and localization; active-site substitutions Asn192 and His148.

"Although the reductase shares more than 60% identity in the amino acid sequence with the mouse tetrameric carbonyl reductase, these two enzymes have many biochemical differences"

PMID:11882650

Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.

Mammalian DCXRs (PANTHER SF2) are NADPH-linked dicarbonyl and L-xylulose reductases.

"homotetramers with NADPH-linked reductase activity for alpha-dicarbonyl compounds, catalyzed the oxidoreduction between xylitol and l-xylulose"

PMID:21477590

DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.

C. elegans DHS-21, in the same PANTHER subfamily (SF3) as chicken DER, reduces L-xylulose with NADPH.

"Recombinant DHS-21 was shown to convert L-xylulose to xylitol using NADPH as a cofactor."

file:CHICK/DER/DER-uniprot.txt

UniProt entry Q8JIS3 (DER_CHICK)

UniProt records L-xylulose reduction for DER as possible only, and PANTHER subfamily SF3 membership.

"May also catalyze the reduction of L-xylulose."