Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000122

AtSubP analysis

PMID:10557364

Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling.

PAD4 was cloned as a lipase-like gene required for salicylic-acid signaling, camalexin synthesis, PR-1 expression, and defense against Pseudomonas.

PMID:10796016

Arabidopsis thaliana EDS4 contributes to salicylic acid (SA)-dependent expression of defense responses: evidence for inhibition of jasmonic acid signaling by SA.

PMID:11574472

Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4.

This source directly supports physical interaction between Arabidopsis EDS1 and PAD4 and the EDS1-PAD4 disease-resistance complex.

PMID:11826312

EDS5, an essential component of salicylic acid-dependent signaling for disease resistance in Arabidopsis, is a member of the MATE transporter family.

PMID:16040633

Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity.

This source supports EDS1-PAD4 associations in nucleus and cytoplasm and notes that EDS1/PAD4 lipase-like proteins lack demonstrated esterase activity.

PMID:16299172

Premature leaf senescence modulated by the Arabidopsis PHYTOALEXIN DEFICIENT4 gene is associated with defense against the phloem-feeding green peach aphid.

PAD4 modulates aphid-induced premature leaf senescence and contributes to basal resistance to green peach aphid.

PMID:16531493

Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7.

PMID:16732289

Conserved requirement for a plant host cell protein in powdery mildew pathogenesis.

Cached text does not provide PAD4-specific support for negative regulation of defense response.

PMID:16813576

Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4.

PMID:17419843

Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis.

PMID:17725549

Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1.

PAD4 controls phloem-based resistance to green peach aphid in an EDS1-independent branch.

PMID:18055613

Lysigenous aerenchyma formation in Arabidopsis is controlled by LESION SIMULATING DISEASE1.

LSD1, EDS1, and PAD4 regulate lysigenous aerenchyma formation in response to hypoxia through ethylene and reactive oxygen signaling.

PMID:19616764

Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis.

PMID:21426427

TREHALOSE PHOSPHATE SYNTHASE11-dependent trehalose metabolism promotes Arabidopsis thaliana defense against the phloem-feeding insect Myzus persicae.

PMID:21434927

Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity.

EDS1 forms molecularly distinct complexes with PAD4 or SAG101; EDS1-PAD4 complex formation supports basal resistance and SA defense mobilization.

PMID:22072959

SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus.

PMID:23275581

Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis.

PMID:28555890

The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator.

PMID:29253890

Leaf shedding as an anti-bacterial defense in Arabidopsis cauline leaves.

PAD4 and other SA-defense components are required for pathogen-triggered cauline leaf abscission as an antibacterial defense response.

PMID:9136026

Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance.

PMID:9634589

PAD4 functions upstream from salicylic acid to control defense responses in Arabidopsis.

file:ARATH/PAD4/PAD4-deep-research-falcon.md

Falcon deep research for Arabidopsis PAD4

PAD4 is an EDS1-family lipase-like immune regulator forming EDS1-PAD4 complexes and acting downstream of TIR-NLR signaling.
Recent synthesis favors noncanonical/pseudoenzymatic immune signaling over demonstrated lipase catalysis.

file:ARATH/PAD4/PAD4-uniprot.txt

UniProt record for Arabidopsis PAD4

UniProt identifies PAD4/Q9S745 as lipase-like PAD4, also named enhanced disease susceptibility 9 and phytoalexin deficient 4, with nuclear and cytoplasmic localization annotations.

file:interpro/panther/PTHR47413/PTHR47413-entries.csv

PANTHER PTHR47413 plant innate immunity regulator family entries

PTHR47413 places Arabidopsis Q9S745/PAD4 in subfamily LIPASE-LIKE PAD4; the broader plant-innate-immunity family label is background context rather than evidence for a specific GO action.