Annotation inferences using phylogenetic trees
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PTHR14102 contains KIAA1614 in SF12; IBA asserts descent from specific ancestral IBD nodes. The current family and target PAINT records retain nuclear, apical-membrane, polarity, cortex and centrosome assertions; their scope must be assessed independently of donor count.
UniProt entry for KIAA1614
Deep research report on KIAA1614
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No primary literature directly characterizes KIAA1614 function. All functional inferences are based on domain architecture. The PAR6_homolog annotation suggests possible scaffold/adaptor role in cell polarity, but this is speculative. Experimental validation through AP-MS, co-IP with Par complex components, and CRISPR perturbation studies would be needed to confirm function.
Cyberian deep research on KIAA1614 function
OpenScientist KIAA1614 Par6-like polarity-scaffold hypothesis report
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The report acknowledges that the family alignment underlying the classification was not examined.
"the exact basis for grouping KIAA1614 with Par6 cannot be fully evaluated without the underlying HMM profile alignment"
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
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Intact-nucleus crosslinking provides the experimental setting for the IntAct-curated KIAA1614-histone H2B association.
"The crosslinking of intact nuclei coupled with sequential detergent fractionation"
UniProtKB KIAA1614 sequence and domain-family annotations