LYS12 (YIL094C, P40495) notes

Pathway context: LYSINE-AMINOAD-PWY-2 step 4 (EC 1.1.1.87, homoisocitrate dehydrogenase).

• Activity: kinetic mechanism of purified enzyme PMID:17223711; Mg-homoisocitrate is substrate PMID:17223711; isocitrate is poor substrate PMID:17223711.
• Location: mitochondria [UniProt:P40495]; MTS plus putative PTS1, but not peroxisomal PMID:28928432.
• Decisions: RCA cytosol MODIFY -> mitochondrion (pathway-diagram default wrong). Generic oxidoreductase IEA MODIFY -> GO:0047046. Mg2+ and NAD binding non-core.