Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Screening of genes involved in cell migration in Dictyostelium.
Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium.
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Disruption of lagB1 (tgrB1) arrests development at the loose aggregate stage and causes strain segregation in chimeras with wild-type cells.
"lagC1 and lagB1 are essential for aggregation and for subsequent development, suggesting common functions"
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lagB1 (tgrB1) and lagC1 (tgrC1) are polymorphic and function together in a common self/kin-recognition mechanism.
"lagB1 and lagC1 participate in a common self- or kin-recognition mechanism"
Self-recognition in social amoebae is mediated by allelic pairs of tiger genes.
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A matching pair of tgrB1 and tgrC1 alleles is necessary and sufficient for attractive self-recognition, mediated by heterotypic binding of their extracellular domains on adjacent cells.
"mediate self-recognition by heterotypic interactions between the extracellular protein domains on adjacent cells"
TgrC1 mediates cell-cell adhesion by interacting with TgrB1 via mutual IPT/TIG domains during development of Dictyostelium discoideum.
Kin recognition protects cooperators against cheaters.
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Kin recognition mediated by tgrB1 and tgrC1 protects cooperators against cheaters.
"kin-recognition genes, tgrB1 and tgrC1"
Assembly of the TgrB1-TgrC1 cell adhesion complex during Dictyostelium discoideum development.
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TgrB1 homodimerization depends on trans-interaction with TgrC1, and coalescence of TgrB1-TgrC1 clusters forms large cell-adhesion complexes.
"the coalescence of TgrB1-TgrC1 clusters results in the formation of large"
Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum.
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To develop beyond aggregation, amoebae must clear an allorecognition checkpoint established by tgrB1 and tgrC1.
"amoebae must clear a checkpoint established by the allorecognition genes tgrB1 and tgrC1"
Gene discovery by chemical mutagenesis and whole-genome sequencing in Dictyostelium.
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TgrB1 and TgrC1 are cell-surface adhesion proteins that form heterophilic interactions in trans; loss impairs cell-cell recognition and development.
"TgrB1 and TgrC1 are cell-surface adhesion proteins that form heterophilic interactions in trans"
A polychromatic 'greenbeard' locus determines patterns of cooperation in a social amoeba.
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The Tgr locus is a polychromatic greenbeard in which partner-specific TgrB1-TgrC1 binding strength predicts partner-specific cooperation.
"partner-specific protein-protein binding strength and recognition specificity"
The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in Dictyostelium allorecognition.
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TgrB1 acts as a receptor with TgrC1 as its ligand in cooperative aggregation and differentiation.
"Here, we show that TgrB1 acts as a receptor with TgrC1 as its ligand in cooperative aggregation and differentiation."
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The TgrB1 cytoplasmic tail becomes phosphorylated upon binding a matching TgrC1 ligand, and dominant tgrB1 alleles act as constitutively activated receptors.
"the cytoplasmic tail of TgrB1 becomes phosphorylated upon binding to a matching TgrC1 ligand"
Identification of novel proteins in the Dictyostelium discoideum chemorepulsion pathway using REMI.
The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum.
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Activation of the TgrB1 receptor confers altruism, whereas tgrB1 inactivation causes allotype-specific cheating.
"activation of the TgrB1 receptor confers altruism"