GPT2 / GAT1 (YKR067W, P36148) notes

Evidence journal (UniProt and cached publications; no paid deep research). Naming trap: the gene GPT2 = GAT1, but UniProt calls the protein "Glycerol-3-phosphate O-acyltransferase 2". SCT1 = GAT2 is called "...acyltransferase 1".

• Gpt2 is a dual G3P/DHAP sn-1 acyltransferase. PMID:11544256
• Gat1 and Sct1 are synthetically lethal. PMID:11544256
• Gpt2 is in the ER (perinuclear and cortical). PMID:19525420
• It is associated with LDs and forms oleate-induced crescents. PMID:22267742
• Phosphorylation restrains Gpt2 activity. PMID:31421179
• Curation decisions: the GPAT and DHAPAT MFs, PA/TAG/phospholipid synthesis, and the ER membrane/LD locations are accepted. The four RCA cytosol rows are removed. "Regulation of triglyceride metabolic process" is marked over-annotated, because the gene product is the regulated enzyme, not a regulator.