Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000104

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:22306653

Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility.

Human DIS3L2 mutations cause Perlman syndrome; inactivation affects mitotic phenotypes and cancer-cell growth.

PMID:23756462

Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA.

Human DIS3L2 is a processive 3′–5′ exoribonuclease that can degrade structured RNA substrates and functions outside the RNA exosome in the tested preparations.
Human-cell depletion slows selected mRNA decay; endogenous and tagged protein show a soluble cytoplasmic pool, and XRN1 co-recovery is RNA dependent.

PMID:24141620

Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs.

Human 885-residue DIS3L2 binds oligo(U) RNA and catalyses divalent-metal-dependent RNA degradation; a D391N substitution abolishes the measured cleavage.
Human-cell and biochemical experiments identify uridylated pre-let-7 as a substrate, with oligo(U) preference but not an absolute inability to degrade other substrates.

PMID:23503588

The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.

Fission-yeast Dis3l2 provides an exosome-independent 3′–5′ RNA decay route with uridylated-RNA preference and genetic interplay with Xrn1.

PMID:23594738

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.

Mouse Dis3l2 preferentially degrades uridylated pre-let-7; depletion accumulates precursors without raising measured mature let-7.

PMID:25119025

Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.

Mouse Dis3l2 binds oligo(U) strongly and degrades oligo(U)-tailed substrates, with preference rather than exclusive substrate recognition.

PMID:27974621

Characterization of a TUTase/RNase complex required for Drosophila gametogenesis.

Drosophila Dis3l2 degrades a mature miR-1010 model substrate and uridylated precursor RNA, supplying distinct grounding for the miRNA-decay IBA.

PMID:34904664

Nuclear poly(A) binding protein 1 (PABPN1) mediates zygotic genome activation-dependent maternal mRNA clearance during mouse early embryonic development.

DIS3L2 contributes to turnover of oligouridylated maternal mRNAs during mouse early embryonic development.

file:human/DIS3L2/DIS3L2-source-guide.md

DIS3L2 source, substrate and propagation guide

Public primary-source locators distinguish human precursor assays, fly mature-miRNA evidence, fission-yeast P-body context and current ancestral-node provenance.