GO_REF:0000033

Annotation inferences using phylogenetic trees

Q9KZ33 is phylogenetically related to characterized ECF sigma factors including L0TCG5 (SigJ) from Mycobacterium tuberculosis

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on inter-ontology links

Regulation of transcription initiation is logically inferred from sigma factor activity via inter-ontology links

file:STRCO/Q9KZ33/Q9KZ33-deep-research-falcon.md

Deep research summary for Q9KZ33/SCO7099

SCO7099 is a predicted ECF sigma factor with sigma2 and sigma4 domain architecture

"The presence of ECF_Sigma-70_Domain and RNA_pol_sigma_r3/r4-like domains strongly supports classification as a bona fide sigma factor capable of directing transcription initiation"
SCO7099 remains functionally uncharacterized with no defined regulon

"For SCO7099, the actual promoter consensus sequence, target genes, and regulon composition remain completely unknown"
Overexpression of SCO7099 failed in a systematic study

"Transformants were not obtained for three sigma factors: SCO4908 (SigQ), SCO5243 (SigH), and SCO7099"