Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferred from sequence similarity using PAINT
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
Gene Ontology annotation based on ARBA rules
The genome sequence of the malaria mosquito Anopheles gambiae.
NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes.
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NDF/GLYR1 destabilizes nucleosomes and facilitates Pol II transcription
"NDF has a PWWP motif, interacts with nucleosomes near the dyad, destabilizes nucleosomes in an ATP-independent manner, and facilitates transcription by Pol II through nucleosomes"
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NDF stimulates H3K56 acetylation by p300 on nucleosomal substrates
"purified recombinant dNDF and hNDF can mediate the stimulation of nucleosomal H3K56 acetylation"
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NDF is recruited to gene bodies upon transcriptional induction
"Upon transcriptional induction, NDF is recruited to the transcribed regions of thousands of genes and colocalizes with a subset of H3K36me3-enriched regions"
LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation.
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NPAC is a cofactor of LSD2 that stimulates H3K4 demethylation
"NPAC directly interacts with LSD2 and positively regulates its H3K4 demethylation activity both in vitro and in vivo"
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The dehydrogenase domain is catalytically inert
"attempts to identify the intrinsic enzymatic activity of NPAC as a potential dehydrogenase"
Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells.
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Npac co-localizes with H3K36me3 in actively transcribed gene bodies
"Npac co-localizes with histone H3K36me3 in gene bodies of actively transcribed genes"
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Npac interacts with p-TEFb and phosphorylated Pol II for elongation
"Npac interacts with positive transcription elongation factor b (p-TEFb), Ser2-phosphorylated RNA Pol II"