Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).
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S. coelicolor genome encodes 7,825 predicted genes on an 8,667,507 bp linear chromosome, the largest bacterial genome sequenced at the time
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The genome contains an unprecedented proportion of regulatory genes and many duplicated gene sets
A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome.
RNA damage in biological conflicts and the diversity of responding RNA repair systems.
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The HAD_SAK_2 (PF18143) family was identified as a previously uncharacterized HAD family within large eukaryotic multidomain RNA-repair-associated proteins; its RNA-repair role is a genome-context prediction, not an assay.
"another previously-uncharacterized HAD family (Supplementary Material)"
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Experimentally characterized RNA ligase-associated HAD domains remove 3'-terminal (cyclic) phosphates from RNA; these belong to other HAD families and are not transferred to SCO2678.
"Experimentally-characterized RNA ligase-associated HAD domains, in a reaction typical of the HAD superfamily (166,167), cleave the cyclic phosphate group from the 3′ end of a RNA fragment"
SCO2678 sequence re-review (HAD motifs, export signals, genomic context)
Deep research report for SCO2678/Q9L243 (Falcon)
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SCO2678 contains a HAD_SAK_2 domain (PF18143) and is a member of the HAD superfamily
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Predicted to function as a secreted HAD-family phosphatase involved in extracellular phosphate scavenging
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S. coelicolor lacks organic phosphate transporters, necessitating extracellular dephosphorylation prior to phosphate uptake
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A PhoP-regulated extracellular 5'-nucleotidase (SCO4152) has been characterized in S. coelicolor, providing functional precedent
Q9L243-uniprot.txt
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The cached UniProt record assigns Q9L243 to eggNOG COG1877.
"DR eggNOG; COG1877; Bacteria."
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The only family signature in the record is Pfam HAD_SAK_2.
"DR Pfam; PF18143; HAD_SAK_2; 1."
OpenScientist deoxyribonucleotide-catabolism audit for SCO2678