Human UniProt Q8WWF8 provides four EF-hand domains and PROSITE-ProRule calcium-binding positions; this is sequence inference, not a direct binding assay. Horse A0A3Q2I3U9 has VGNC:16048 CAPSL identity, corresponding EF-hand domains and 202/208 identical aligned human residues (97.1%; see the horse alignment report). The 17-residue horse N-terminal extension does not erase the aligned EF-hand core.
PMID:39264149(https://pubmed.ncbi.nlm.nih.gov/39264149/), DOI 10.7554/eLife.96907, full text cached: “CAPSL is localized in both the cytoplasm and the nucleus of cells”. Human HREC depletion directly impairs endothelial phenotypes; endothelial-specific mouse knockout supplies in vivo retinal angiogenesis evidence. The paper does not establish a direct CAPSL–MYC physical interaction or enzymatic activity.
PMID:31186450(https://pubmed.ncbi.nlm.nih.gov/31186450/), full text cached, examines human adipose-derived cells and mouse 3T3-L1 cells. “CapslKO cells showed enhanced propensity for differentiation, while CapslOE cells showed no proper lipid accumulation”. These results suggest regulation of adipogenesis and autophagic flux but do not establish an intrinsic enzyme function or a horse tissue-specific phenotype.
Horse record is unreviewed and has genome-sequencing identification rather than horse-specific functional experiments. A dedicated horse Edison report is not warranted by these sources. A completed human Falcon report has been inspected; primary sources above are independently inspected and cached.
The Falcon report retrieved a June 2026 mechanistic preprint, Cai et al., DOI:10.64898/2026.06.11.731632, independently verified through Europe PMC PPR1251699 (raw source cached in the human directory). Its abstract states: “We identify the calcium-binding protein CAPSL as a lumenal MIP that forms a pseudo-helical spiral and stabilizes microtubules in vitro .” The native structure is bovine tracheal cilia, a legitimate mammalian comparison; the report describes recombinant human CAPSL experiments, but those assay details have not yet been independently inspected because full-text retrieval was unavailable. This is a substantial structural lead, not proof supplied by an AI conclusion. It supports a provisional ciliary structural role and makes the nuclear/cytoplasmic observations compatible with multiple cellular pools.
The Falcon synthesis missed the independently inspected peer-reviewed FEVR and adipogenesis studies above. Retain their evidence rather than adopting its claim that no human phenotype study exists. The calcium-binding assignment remains an EF-hand inference; direct calcium occupancy/affinity measurements were not established.