Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.
DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.
DJ-1 has a role in antioxidative stress to prevent cell death.
hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria.
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis.
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease.
DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor.
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells.
Novel interaction partners of Bardet-Biedl syndrome proteins.
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1.
DJ-1 binds to mitochondrial complex I and maintains its activity.
Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress.
Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death.
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
Proteomic characterization of the human sperm nucleus.
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.
DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway.
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.
Human DJ-1 and its homologs are novel glyoxalases.
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection.
DJ-1 cooperates with PYCR1 in cell protection against oxidative stress.
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.
Structure of Cu(I)-bound DJ-1 reveals a biscysteinate metal binding site at the homodimer interface: insights into mutational inactivation of DJ-1 in Parkinsonism.
The role of oxidative stress in Parkinson's disease.
Glucocerebrosidase is shaking up the synucleinopathies.
DJ-1 is a copper chaperone acting on SOD1 activation.
Regulation of the VHL/HIF-1 pathway by DJ-1.
DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis.
Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.
A proteome-scale map of the human interactome network.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte.
Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification.
Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.
Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.
Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.
Reversible histone glycation is associated with disease-related changes in chromatin architecture.
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
PIAS2-1 SUMOylates PARK7 with SUMO1
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
Parkin transfers Ub to misfolded proteins
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
PolyUb-Misfolded proteins bind vimentin to form aggresome
Aggresome dissociates from dynein and microtubule