PIWIL1 curation notes

2026-09-20 IBA re-review

Corrected P-granule and dense-body ontology definitions; retained a reported nuclear tumor pool as non-core; restored target-mRNA binding, translational regulation, mRNA destabilization, piRNA processing and valid broad parent annotations. Withdrew unverified kinase-binding and heterochromatin-transfer exclusions.

Evidence inspected: PMID:28634417(https://pubmed.ncbi.nlm.nih.gov/28634417/), PMID:31835033(https://pubmed.ncbi.nlm.nih.gov/31835033/), PMID:24787618(https://pubmed.ncbi.nlm.nih.gov/24787618/), PMID:38491008(https://pubmed.ncbi.nlm.nih.gov/38491008/).

Remaining questions:

• Trace the specific Ensembl protein-kinase-binding donor assay.
• Determine whether the PIWIL1 ortholog performs a direct step in piRNA-mediated heterochromatin formation, rather than inferring participation from overall transposon silencing.

The project audit records all changed row indices and decisions in projects/IBA_REVIEW/rereview-2026-09-20/localization.yaml.