Selected accession A0A9L0SB67; ordinary UniProt record is TrEMBL and cites genome sequencing/submission rather than a gene-specific functional experiment. Human evidence is summarized in the paired human investigation. Sequence comparison records the exact target gaps and transfer limits. The targeted Europe PMC search found no decisive gene-specific horse functional assay warranting a separate horse Edison investigation; general omics/association hits were not counted as mechanistic validation.
Mitochondrial aspartate-tRNA synthetase must accommodate structurally unusual mitochondrial tRNA(Asp); the 2013 structure compares that accommodation with bacterial AspRS. Cross-aminoacylation of bacterial and mitochondrial tRNA(Asp) is a taxonomic/substrate-structure breadth claim, whereas acceptance of tRNA(Asn) is a different aminoacylation-specificity claim. The human GOA includes the latter, so the original experiments matter. The inspected 2013 full text did not settle that point and the 2005 characterization is abstract-only in the cache. Retaining uncertainty is appropriate. Matrix localization is the primary placement, but additional membrane-associated or extracellular activities cannot be dismissed just from that default.
Sources: PMID:15779907(https://pubmed.ncbi.nlm.nih.gov/15779907/), PMID:23275545(https://pubmed.ncbi.nlm.nih.gov/23275545/).