Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
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Systematically characterized DNA binding specificities of 542 human TFs using SELEX
"By analysis of 542 human TFs with methylation-sensitive SELEX"
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OLIG2 was among the transcription factors analyzed
"systematic analysis of DNA binding specificities of full-length TFs"
A reference map of the human binary protein interactome.
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Large-scale yeast two-hybrid interactome mapping (HuRI)
"we present a human 'all-by-all' reference interactome map"
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Identified protein-protein interactions for OLIG2
"HuRI has approximately four times as many such interactions"
Deep research synthesis on OLIG2 function
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OLIG2 is a Class B/E basic helix-loop-helix transcription factor that binds E-box DNA motifs to regulate lineage programs
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OLIG2 orchestrates neuron-glia fate decisions and is required for OPC specification and oligodendrocyte differentiation
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OLIG2 represses p21 and antagonizes p53 acetylation to support replication competence
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Functional partners include ASCL1, SOX10, and NKX2.2 in the oligodendroglial gene regulatory network
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OLIG2 is induced by Sonic hedgehog (Shh) and participates in cross-talk with FGF and EGFR signaling
Comprehensive OLIG2 gene research with detailed citations
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OLIG2 homodimers function as transcriptional repressors while heterodimers with E47 can activate transcription
"OLIG2 homodimers tend to function as transcriptional repressors, while heterodimers with E47 can activate transcription of target genes such as the Sox10 enhancer"
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Phosphorylation of OLIG2 at Serine 147 regulates the motor neuron-to-oligodendrocyte fate switch
"Serine 147, located within the helix-loop-helix domain, is the key regulatory residue. When phosphorylated, OLIG2 preferentially forms homodimers...when S147 is dephosphorylated, OLIG2 shifts to preferentially forming heterodimers with NGN2"
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OLIG2 interacts with chromatin remodeler BRG1/SMARCA4 to initiate oligodendrocyte differentiation
"OLIG2 functions as a "pre-patterning factor" that directs BRG1 to oligodendrocyte-specific enhancers before differentiation begins"
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OLIG2 recruits SETDB1 for H3K9me3 repressive modification on genes like Sox11
"OLIG2 recruits the histone methyltransferase SETDB1 for H3K9me3 modification on the Sox11 gene"
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Nuclear-to-cytoplasmic translocation of OLIG2 is essential for astrocyte differentiation
"The translocation of OLIG2 to the cytoplasm is promoted by activated AKT kinase through the PI3K signaling pathway"
The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2
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OLIG2 and NKX2.2 co-expression promotes oligodendrocyte differentiation through transcriptional repression
"Coexpression of Olig2 with Nkx2.2 in the spinal cord promotes ectopic and precocious oligodendrocyte differentiation. Both proteins function as transcriptional repressors in this assay."
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages
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OLIG2 knockout mice lose both motor neurons and oligodendrocytes, with cells converting to astrocyte fate
"motoneurons are largely eliminated and oligodendrocytes are not produced"
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First evidence that a single gene controls specification of two neural cell types
"Our data provide the first evidence that a single gene mutation leads to the loss of two cell types, motoneuron and oligodendrocyte."
Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch
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S147 phosphorylation state determines motor neuron vs oligodendrocyte fate
"We found that Serine 147 in the helix-loop-helix domain of OLIG2 was phosphorylated during MN production and dephosphorylated at the onset of OLP genesis"
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S147A mutation abolishes motor neuron production without preventing oligodendrocyte production
"Mutating Serine 147 to Alanine (S147A) abolished MN production without preventing OLP production in transgenic mice, chicks, or cultured P19 cells"