Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.
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DAF-16 is a direct target of AKT phosphorylation
"Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways."
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AKT phosphorylation generates 14-3-3 binding sites
"Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways."
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14-3-3 binding regulates nuclear/cytoplasmic distribution
"Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways."
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14-3-3 binding inhibits DAF-16 DNA binding
"Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways."
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PI 3-kinase/AKT signaling inhibits DAF-16 transcription activity
"Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways."
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.
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DAF-2 pathway prevents DAF-16 nuclear accumulation
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling."
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Disrupting AKT phosphorylation sites causes nuclear accumulation
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling."
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Both sensory neurons and germline regulate DAF-16 localization
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling."
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DAF-16 required for lifespan extension in daf-2 mutants
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling."
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.
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Human FKHRL1 can partially replace DAF-16
"Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway."
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DAF-16 is major output of insulin signaling
"Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway."
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daf-2 insulin signaling via AKT controls DAF-16 nuclear localization
"Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway."
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daf-7 TGF-beta signaling also regulates DAF-16 localization
"Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway."
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.
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DAF-16::GFP worms grow slower but live longer
"daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans."
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Starvation, heat, and oxidative stress cause DAF-16 nuclear localization
"daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans."
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DAF-16 is inhibited from nuclear entry by daf-2 and akt-1/akt-2
"daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans."
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
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SGK-1 forms complex with AKT kinases
"C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span."
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All three kinases phosphorylate DAF-16
"C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span."
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SGK-1 is crucial for control of stress response and longevity
"C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span."
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
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Beta-catenin binds directly to FOXO
"Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
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BAR-1 enhances DAF-16 transcriptional activity
"Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
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BAR-1 required for oxidative stress-induced sod-3 expression
"Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
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Loss of BAR-1 reduces DAF-16 activity in dauer formation and lifespan
"Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.
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Two 14-3-3 proteins are SIR-2.1 binding partners
"C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span."
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14-3-3 required for sir-2.1-induced life-span extension
"C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span."
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SIR-2.1 can bind DAF-16 in 14-3-3-dependent manner after heat stress
"C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span."
The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans.
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FTT-2 knockdown causes DAF-16 nuclear accumulation
"The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans."
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FTT-2 forms complex with DAF-16
"The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans."
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FTT-2 regulates DAF-16 by cytoplasmic sequestration
"The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans."
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
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DAF-16 targets genes that regulate tumor growth
"DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans."
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Many genes also affect normal aging
"DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans."
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DAF-16 regulates p53-dependent apoptosis
"DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans."
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
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IIS kinases AKT-1, -2, and SGK-1 phosphorylate both DAF-16 and SKN-1
"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans."
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Reduced IIS leads to DAF-16 nuclear accumulation
"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans."
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
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Conditioning requires the insulin/IGFR pathway
"Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity."
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DAF-16 contributes to pathogen resistance
"Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity."
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.
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PRMT-1 methylates DAF-16, blocking phosphorylation by AKT
"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16."
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Methylation promotes DAF-16 nuclear translocation
"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16."
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prmt-1 required for stress tolerance and fat storage
"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16."
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FTT-2 sequesters DAF-16 in cytoplasm
"Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16."
RPN-6 determines C. elegans longevity under proteotoxic stress conditions.
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DAF-16 activates rpn-6 expression
"RPN-6 determines C. elegans longevity under proteotoxic stress conditions."
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rpn-6 is sufficient for proteotoxic stress resistance
"RPN-6 determines C. elegans longevity under proteotoxic stress conditions."
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DAF-16 enhances 26S proteasome assembly
"RPN-6 determines C. elegans longevity under proteotoxic stress conditions."
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
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daf-16 affects downstream steps in dauer pathway
"Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans."
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Epistasis analysis places daf-16 in linear pathway
"Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans."
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
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DAF-16 ChIP analysis in germline-less mutants
"A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants."
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Germline removal causes soma-to-germline transformation
"A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants."
PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity.
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PQM-1 and DAF-16 regulate non-overlapping gene sets
"PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity."
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Nuclear localization of DAF-16 and PQM-1 are mutually exclusive
"PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity."
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.
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MATH-33 deubiquitinase binds and stabilizes DAF-16
"The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity."
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DAF-16 nuclear localization is affected by MATH-33
"The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity."
Regulation of aging and age-related disease by DAF-16 and heat-shock factor.
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DAF-16 and HSF-1 work together for longevity
"Regulation of aging and age-related disease by DAF-16 and heat-shock factor."
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Both transcription factors regulate stress responses
"Regulation of aging and age-related disease by DAF-16 and heat-shock factor."
A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway.
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DAF-16 represses vit-2 expression in intestine
"A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway."
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DAF-16 has post-developmental functions
"A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway."
Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.
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DAF-16 and HSF-1 act synergistically for innate immunity
"Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity."
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Defense response to Gram-negative bacteria requires both factors
"Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity."
Intergenerational pathogen-induced diapause in Caenorhabditis elegans is modulated by mir-243.
Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep.
The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.
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DAF-16 represses natc-1 expression
"The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation."
Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4.
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DAF-16 represses ubh-4 deubiquitinase expression
"Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4."
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DAF-16 enhances proteasome activity
"Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4."
Specificity and complexity of the Caenorhabditis elegans innate immune response.
Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation.
A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication.
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
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DAF-16 affects lifespan in context of synaptic signaling
"Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development."
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DAF-16 affects neuromuscular junction development
"Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development."
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.
The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption.
Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.
RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.
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HEL-1 RNA helicase promotes DAF-16 activity
"RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans."
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DAF-16 interacts with HEL-1
"RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans."
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.
A fasting-responsive signaling pathway that extends life span in C. elegans.
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DAF-16 mediates lifespan extension by fasting signaling
"A fasting-responsive signaling pathway that extends life span in C. elegans."
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DAF-16 mediates fasting/starvation responses
"A fasting-responsive signaling pathway that extends life span in C. elegans."
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan.
A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process.
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daf-16 mutants are dauer-defective
"A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process."
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DAF-16 promotes dauer formation
"A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process."
NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.
Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.
Combined informatic and expression screen identifies the novel DAF-16 target HLH-13.
Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis.
The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.
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DAF-16 regulates transcription with JNK-1 input
"The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness."
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JNK promotes DAF-16 nuclear translocation
"The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness."
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.
A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans.
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
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DAF-16 contributes to innate immune response
"p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans."
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p38 MAPK and DAF-16 regulate overlapping genes
"p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans."
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.
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RLE-1 E3 ubiquitin ligase ubiquitinates DAF-16
"RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination."
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DAF-16 interacts with RLE-1
"RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination."
Deep research report on daf-16