Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.
NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes.
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.
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NUFIP, with BCD1, NOP17, TAF9 and the ATPases TIP48/TIP49, is a pre-snoRNP assembly factor; NUFIP bridges interactions between core box C/D proteins in a partially reconstituted pre-snoRNP.
Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
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Upon mTORC1 inhibition/starvation, NUFIP1 redistributes from the nucleus to autophagosomes, binds ribosomes (with ZNHIT3), and delivers them to autophagosomes by directly binding LC3B; a NUFIP1 mutant unable to bind LC3B cannot support ribosome degradation. NUFIP1 is the selective-autophagy receptor for ribosomes (ribophagy), promoting cell survival under starvation.