file:human/DNAJA4/DNAJA4-deep-research-falcon.md

Falcon deep research report for DNAJA4

Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:20651708

The HSP70 chaperone machinery: J proteins as drivers of functional specificity.

PMID:21231916

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.

PMID:23142051

Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.

PMID:25036637

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

Reactome:R-HSA-3371422

ATP hydrolysis by HSP70

Reactome:R-HSA-3371503

STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein

Reactome:R-HSA-3371590

HSP70 binds to HSP40:nascent protein

DOI:10.1016/j.molcel.2021.04.012

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DNAJA4 is positioned in the densely connected cytoplasmic class A JDP core of the human Hsp70 network, with robust interactions with DNAJA1, DNAJA2, and DNAJB1.

DOI:10.3390/biology12030416

Profiling the Hsp70 chaperone network in heat-induced proteotoxic stress models of human neurons.

DNAJA4 is among the chaperone/co-chaperone genes commonly upregulated across three neuronal models after heat stress (log2 fold-change 1.5-5 at 1 h post-heat shock).

DOI:10.1038/s41419-023-06225-w

DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.

DNAJA4 promotes ubiquitin-proteasome-dependent degradation of MYH9 via PSMD2 recruitment, suppressing EMT and metastasis in NPC.
DNAJA4 promoter hypermethylation and downregulation in NPC; DAC demethylation restores DNAJA4 levels at least 15-fold in NPC cell lines.

DOI:10.3390/ijms222413527

Regulation of p53 and cancer signaling by heat shock protein 40/J-domain protein family members.

DNAJA4 can be epigenetically silenced in cancers; reduced DNAJA4 expression due to promoter methylation correlates with poorer disease-free survival in stomach adenocarcinoma, and hypermethylation is observed in rhabdomyosarcoma.

DOI:10.1098/rstb.2016.0534

DNAJ proteins in neurodegeneration - essential and protective factors.

Review situating DNAJA4 within the DNAJA subfamily with canonical class A JDP domain composition (J-domain, G/F region, Zn-binding region, and C-terminal client-binding/dimerization region).