Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Mechanisms for asporin function and regulation in articular cartilage.
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Asporin blocks TGF-beta1-induced chondrogenesis in human articular cartilage.
"Asporin blocks chondrogenesis and inhibits TGF-beta1-induced expression of matrix genes and the resulting chondrocyte phenotypes."
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Asporin co-localizes with TGF-beta1 on the cell surface and blocks its binding to the type II receptor.
"Asporin inhibits TGF-beta/Smad signaling upstream of TGF-beta type I receptor activation in vivo by co-localizing with TGF-beta1 on the cell surface and blocking its interaction with the TGF-beta type II receptor."
Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization.
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Asporin binds type I collagen.
"Here, we show that asporin binds collagen type I."
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The polyaspartate domain binds calcium.
"We demonstrate that the polyaspartate domain binds calcium and regulates hydroxyapatite formation in vitro."
Proteomics characterization of extracellular space components in the human aorta.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.
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Asporin binds TGF-beta directly.
"In vitro binding assays showed a direct interaction between asporin and TGF-beta."
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Asporin suppresses TGF-beta-mediated chondrogenic gene expression.
"Asporin suppresses TGF-beta-mediated expression of the genes aggrecan (AGC1) and type II collagen (COL2A1) and reduced proteoglycan accumulation in an in vitro model of chondrogenesis."
PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization.
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PLAP-1/asporin inhibits PDL mineralization.
"We report that PLAP-1/asporin is also expressed specifically and predominantly in the periodontal ligament (PDL) and that it negatively regulates the mineralization of PDL cells."
PLAP-1/asporin inhibits activation of BMP receptor via its leucine-rich repeat motif.
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Asporin prevents BMP-2 binding to BMPR-IB.
"Recombinant PLAP-1/asporin inhibited BMP-2-induced cytodifferentiation of PDL cells and competitively prevented BMP-2 from binding to the BMP receptor-IB (BMPR-IB), resulting in inhibition of BMP-dependent activation of Smad proteins."
UniProt entry Q9BXN1 (ASPN_HUMAN)
Affinage mechanistic annotation for ASPN (human)