Independent recruitment of F box genes to regulate hermaphrodite development during nematode evolution.
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she-1 is a critical regulator of hermaphrodite development in C. briggsae.
"We identified a critical regulator of hermaphrodite development in C. briggsae, named she-1."
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Double-mutant analysis places she-1 upstream of tra-2, the same position fog-2 occupies in the C. elegans sex-determination pathway.
"Analysis of double mutants indicates that she-1 acts upstream of tra-2 in C. briggsae, just as fog-2 does in C. elegans."
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she-1 encodes a novel F-box protein created by a recent gene duplication.
"she-1 encodes a novel F box protein that was created by a recent gene duplication."
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SHE-1 does not bind GLD-1, the partner through which C. elegans FOG-2 acts, so its molecular activity differs from that of FOG-2.
"Whereas FOG-2 acts through GLD-1 in C. elegans, SHE-1 does not bind GLD-1 in C. briggsae."
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Null mutations of she-1 are temperature sensitive.
"null mutations of she-1 are temperature sensitive"