Gene Ontology annotation through association of InterPro records with GO terms.
UniRule automatic annotation.
Combined Automated Annotation using Multiple IEA Methods.
Transcriptional organization of the czc heavy-metal homeostasis determinant from Alcaligenes eutrophus.
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Establishes that CzcS and CzcR form a two-component regulatory system involved in Zn2+, Co2+, and Cd2+-inducible regulation of czcCBA transcription.
"Experiments on (i) growth of these strains in liquid culture containing 5 mM Zn2+, (ii) induction of the beta-galactosidase in the reporter strains by zinc, cobalt, and cadmium, and (iii) cDNA analysis of czcCBA mRNA synthesis under inducing and noninducing conditions showed that the CzcRS two-component regulatory system is involved in Czc regulation."
Curation Notes for cusS (VPARA_44940, A0A0H2MBG2) in Variovorax paradoxus TBEA6
UniProtKB record for Variovorax paradoxus TBEA6 cusS (A0A0H2MBG2)
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VPARA_44940 is a 443-amino-acid heavy-metal sensor histidine kinase classified in NCBIfam:TIGR01386 (cztS_silS_copS) and PANTHER:PTHR45436:SF9.
"DR NCBIfam; TIGR01386; cztS_silS_copS; 1."
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Contains two transmembrane helices (residues 21-41 and 145-168), a cytoplasmic HAMP domain (residues 169-222; PROSITE:PS50885), and a C-terminal histidine kinase domain (residues 230-443; PROSITE:PS50109) with autocatalytic phosphohistidine site His-233.
"FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364088"
FT TRANSMEM 145..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364088"
FT DOMAIN 169..222
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 230..443
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT MOD_RES 233
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00107"
"