Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
DROME/CG10359/CG10359-uniprot.txt
CG10359 isoform comparison and FReD phylogenetic placement (2026-10-20 re-review)
-
B7Z0B2 is the longest of four unreviewed CG10359 products; the others lack a 26-residue internal segment upstream of the FReD. It is a full-length isoform, not a fragment.
"B7Z0B2 is therefore a full-length isoform of the gene, not a fragment;"
-
CG10359 is in insect/nematode PANTHER subfamily SF327, with no characterised members, separate from FIBCD1 (SF45) and FCN1 (SF377).
"no vertebrate protein and no experimentally"
PAINT IBD annotations for PANTHER family PTHR19143
Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin.
-
Human FIBCD1, the donor of the chitin-binding and membrane ISS rows, is a type II transmembrane receptor whose fibrinogen domain binds acetylated ligands including chitin.
"FIBCD1 is a high-affinity receptor for chitin and chitin fragments."
Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.
Dying cells protect survivors from radiation-induced cell death in Drosophila.
-
CG10359, a putative angiopoietin homolog, is induced after irradiation in wing discs, but a deficiency deleting it did not affect the tested Tie-dependent protection.
"The results with Pvf2 and CG10359 were negative (not shown)"
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder.
-
Fly dFibcd1/CG10359 knockdown produces neuromuscular-junction defects and motor-related behavioral deficits.
"Gene knockdown in flies resulted in morphological disruption of the neuromuscular junction and motor-related behavioural deficits."
-
The paper names CG10359 a potential FIBCD1 orthologue from FReD similarity, but PANTHER separates them into different subfamilies.
"we identified the D. melanogaster gene CG10359 as a potential orthologue of FIBCD1"
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking.
-
The larval tissue-secretome map identifies B7Z0B2/CG10359 in the high-confidence tissue-secreted protein set from muscle, heart, wing disc and neurons.
"We removed B7Z0B3 (CG10359) from muscle, because B7Z0B2 (CG10359) was identified from muscle/heart/wingdisc/neurons."
-
FlyPhoneDB2 predicts CG10359 as a candidate muscle-secreted ligand for imaginal-disc Mew, an integrin alpha subunit; this is suggestive of an extracellular interaction but does not by itself prove matrix residence or justify a new binding annotation.
"candidate inter-organ ligands, including muscle-secreted CG10359 binding to Multiple edematous wings (Mew) in imaginal discs"