GO annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified annotations to orthologs by curator judgment
Annotation inferences using phylogenetic trees
GO annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
GO annotation based on curation of immunofluorescence data (HPA)
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Automatic GO annotation from UniProtKB-KW mapping
Combined Automated Annotation using Multiple IEA Methods
A novel family of cell surface receptors with tyrosine kinase-like domain.
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Early characterization placing ROR1 as a cell-surface receptor tyrosine kinase (legacy classification).
"These proteins, Ror1 and Ror2, share 58% overall amino acid identity and a structure indicative of cell surface molecules. ... The cytoplasmic portion contains the tyrosine kinase-like domain which (in Ror2) appears to be associated with protein kinase activity in vitro,"
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.
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ROR1 is an oncofetal antigen and a receptor for Wnt5a, supporting its Wnt-protein binding / Wnt receptor function.
"identify ROR1 as an oncofetal antigen and receptor for Wnt5a"
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
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ROR1 is classified as a pseudokinase that does not bind nucleotide, supporting the NOT ATP binding annotation.
"A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties"
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.
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ROR1 is essential for innervation of auditory hair cells and hearing, and acts as a Wnt receptor (supports Wnt receptor activity and sensory perception of sound).
"ROR1 is essential for proper innervation of auditory hair cells and hearing"
IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
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IGFBP5 is a ROR1 ligand; ROR1 functions as a signaling receptor promoting invasion via a ROR1/HER2-CREB axis (supports signaling receptor activity).
"IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis"
Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains.