Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa.
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An np20 transposon mutant has reduced transcription of quorum-sensing-controlled genes.
"Third, mutations in the putative regulators np20 and PA3946 reduced transcription of a number of quorum sensing-controlled genes, showing that these functions participate in the quorum-sensing regulatory network."
The transcriptional regulator Np20 is the zinc uptake regulator in Pseudomonas aeruginosa.
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Zinc-dependent repression of znuA is lost in the zur mutant.
"transcription of znuA was repressed in a zinc-dependent manner in strain PAO1, however zinc-dependent transcriptional repression was alleviated in strain PAO-Zur"
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Recombinant Zur binds the znuA promoter specifically and zinc-dependently.
"Electrophoretic mobility shift assays also revealed that recombinant ZurPA specifically binds to the promoter region of znuA and does not bind in the presence of the zinc chelator"
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The zur mutant accumulates more intracellular zinc.
"Intracellular zinc concentrations in strain PAO-Zur (Δzur) were found to be higher than those for strain PAO1"
np20 (PA5499) review notes