Septin2 (Sep2, P54359) notes

SEPT6-class septin; subunit of Sep1-Sep2-Pnut complex; Sep5 is its retrogene paralog.

• Sep2 alone lacks GTPase activity PMID:25355953, does not exchange GTP PMID:25355953, structural role PMID:25355953. GOA already carries a NOT|enables GTPase activity IDA from this paper.
  -> REMOVE GTPase IBA/ISS and the complex-level IDA (PMID:8636235; contradicted by direct measurement); ACCEPT the NOT row.
• Sep2/Sep5 redundancy PMID:24433211; oogenesis PMID:24433211
  -> 'regulation of cell cycle' IGI marked over-annotated (proliferation defect best explained by cytokinesis).
• Wound repair PMID:38728140
• UniProt spindle location is by similarity only [file:DROME/Septin2/Septin2-uniprot.txt "SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, spindle"] -> marked over-annotated.

Deep research (falcon) follow-up

The falcon report independently concludes that Sep2 is a structural, GTP-bound subunit without detectable intrinsic GTPase activity (Akhmetova 2015; Field 1996), supporting the REMOVE/over-annotated decisions on GTPase rows and the accepted NOT annotation. It also cites Sep2-GFP stability at spermatocyte cleavage furrows and anillin dependence (Goldbach et al. 2010), not in GOA or the cache; no annotations were added.