GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms.

GO_REF:0000033

Annotation inferences using phylogenetic trees

RASA3 clusters with other GAP1 family members that share GTPase activator activity

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods.

PMID:10828023

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

GAP1(IP4BP)/RASA3 localizes to plasma membrane fractions in human platelets

"The PM fractions were found to contain the type III (1,4,5)IP(3)R and GAP1(IP4BP) in contrast to IM"
IP4 induces Ca2+ flux in platelet plasma membrane preparations

"Ca(++) release activities were present with both (1,4,5)IP(3) and (1, 3,4,5)IP(4)"
Type III IP3R and GAP1(IP4BP) are found in plasma membrane, while Type I IP3R is in intracellular membranes

"the type III receptor and GAP1(IP4BP) associated with cation entry in human platelets and the type I receptor involved with Ca(++) release from intracellular stores"

PMID:7637787

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family.

RASA3/GAP1(IP4BP) binds inositol 1,3,4,5-tetrakisphosphate (IP4) with high affinity

"Its high affinity for Ins(1,3,4,5)P4, and its exquisite specificity for this isomeric configuration"
RASA3 shows GAP activity against both Rap and Ras in vitro

"In vitro it shows GAP activity against both Rap and Ras"
Ras GAP activity is inhibited by phospholipids and stimulated by IP4

"only the Ras GAP activity is inhibited by phospholipids and is specifically stimulated by Ins(1,3,4,5)P4"

Reactome:R-HSA-5658231

RAS GAPs stimulate RAS GTPase activity

Reactome:R-HSA-5658435

RAS GAPs bind RAS:GTP

file:human/RASA3/RASA3-deep-research-falcon.md

Deep research on RASA3 - Falcon/Edison provider

RASA3 is a dual-specificity GAP for Rap1 (primary) and Ras
Regulated by P2Y12-Gi-PI3K signaling through PIP3 binding to PH domain
Critical for platelet homeostasis and T cell trafficking

file:human/RASA3/RASA3-deep-research-openai.md

Deep research on RASA3 - OpenAI provider

RASA3 is bifunctional RasGAP with activity on both Ras and Rap1 GTPases
PIP3 binding inhibits GAP activity - feedback mechanism
Mouse scat mutant (G125V) causes severe hematopoietic defects
Human RASA3 mutations cause Rasopathy-like syndrome
Acts as gatekeeper of T cell activation and adhesion