Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
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C. elegans BBS homologues are expressed exclusively in ciliated neurons
"all available Caenorhabditis elegans BBS homologues are expressed exclusively in ciliated neurons
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BBS genes contain RFX regulatory elements associated with ciliogenesis
"contain regulatory elements for RFX, a transcription factor that modulates the expression of genes associated with ciliogenesis and intraflagellar transport
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Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
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BBS proteins localize at base of cilia and move along axoneme
"C. elegans BBS proteins localize predominantly at the base of cilia, and like proteins involved in intraflagellar transport (IFT), a process necessary for cilia biogenesis and maintenance, move bidirectionally along the ciliary axoneme
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BBS-7 and BBS-8 required for normal IFT protein localization and motility
"BBS-7 and BBS-8 are required for the normal localization/motility of the IFT proteins OSM-5/Polaris and CHE-11
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BBS mutations cause structural and functional cilia defects
"mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia
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The BBSome controls IFT assembly and turnaround in cilia.
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BBS-1 is required for proper BBSome assembly and ciliary localization
"the BBSome is required for assembling IFT particles at both ciliary base and tip
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bbs-1(jhu598) G207D mutation causes defective IFT turnaround at ciliary tip
"we identified two hypomorphic mutations in dyf-2 and bbs-1 as the only mutants showing normal anterograde IFT transport but defective IFT turnaround at the ciliary tip
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BBSome assembles IFT particles at ciliary base
"the BBSome (refs 3, 4), a group of conserved proteins affected in human Bardet-Biedl syndrome(5) (BBS), assembles IFT complexes at the ciliary base, then binds to the anterograde IFT particle in a DYF-2- (an orthologue of human WDR19) and BBS-1-dependent manner
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BBS-1 interacts with BBS-7 and BBS-9 in same complex (BiFC)
"In wild-type animals, fluorescence complementation can be observed in BBS-1–BBS-7 and BBS-1–BBS-9 pair, indicative of the coexistence of these three BBS proteins in the same complex
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BBSome regulates IFT-B recycling for retrograde transport
"the defects of bbs-1(jhu598) animals completely phenocopy the observations in dyf-2(jhu616): IFT-A and IFT-B associate in anterograde but not retrograde IFT and IFT-B accumulates at the ciliary tip
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The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans
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C. elegans lacks Smoothened and canonical Hedgehog signaling
"obvious Smo and Hh homologs are absent whereas PTC, PTC-related (PTR), and a large family of nematode Hh-related (Hh-r) proteins are present
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Patched homologs (PTC-1, PTC-3) function independently of Smo in nematodes
"these genes do not require Smo for activity and that they function in multiple aspects of C. elegans development
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Deep research report on bbs-1