Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors
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NPHP-1 and NPHP-4 are expressed in a subset of sensory neurons
"Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors."
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GFP-tagged proteins localize to ciliated sensory endings
"Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors."
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The cilia of single mutants are intact
"Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors."
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nphp-1;nphp-4 double mutant males are response defective
"Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors."
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NPHP-1 and NPHP-4 play redundant roles in ciliary sensory signal transduction
"Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors."
The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure
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NPHP-1 and NPHP-4 localize to ciliary transition zones
"The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure."
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Loss of nephrocystins causes changes in localization of specific ciliary components
"The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure."
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nphp-4 mutations cause B tubule defects in amphid channel cilia
"The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure."
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NPHP-4 regulates ciliary localization of OSM-6, OSM-3, and BBS proteins
"The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure."
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Nephrocystins act globally at the TZ to regulate ciliary access
"The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure."
Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis
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B9 proteins function redundantly with nephrocystins
"Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis."
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Combined mutations cause cilia and dendrite defects
"Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis."
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B9 proteins form a complex at the base of cilia
"Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis."
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
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MKS-1, MKSR-1, MKSR-2 localize to transition zones
"Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins."
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Their localization is largely co-dependent
"Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins."
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mks/mksr mutant combinations show increased lifespan phenotype
"Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins."
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
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NPHP-4 is part of the NPHP module at the TZ
"MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis."
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MKS and NPHP modules work together for TZ function
"MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis."
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TZ proteins establish basal body membrane attachments
"MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis."
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TZ proteins restrict accumulation of nonciliary components in cilia
"MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis."
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MKS-5 is central for anchoring both modules
"MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis."
Caenorhabditis elegans ciliary protein NPHP-8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation.
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NPHP-8 colocalizes with NPHP-4 at the transition zone
"Caenorhabditis elegans ciliary protein NPHP-8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation."
TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone
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JBTS-14/TMEM237 genetically interacts with nphp-4
"TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone."
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Double mutants have basal body-TZ anchoring defects
"TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone."
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Both require RPGRIP1L/MKS-5 for proper TZ localization
"TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone."
TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome
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TMEM-107 functions redundantly with NPHP-4
"TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome."
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Double mutants have TZ docking and Y-link assembly defects
"TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome."
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TMEM-107 is part of the MKS module
"TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome."
A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4
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Screen identified mks-1, mks-2, mks-5 as nphp-4 interactors
"A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4."
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Novel osm-3(yhw66) allele shows specific interaction with nphp-4
"A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4."
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Double mutants lack distal segments and are Dyf
"A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4."
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NPHP-4 influences localization and function of OSM-3 kinesin
"A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4."
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone
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CEP-290 is required for MKS module assembly
"MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone."
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MKS-5 is central to TZ assembly pathway
"MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone."
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cep-290;nphp-4 double mutants fail to dye-fill
"MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone."
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis
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Girdin localizes to proximal centrioles
"A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis."
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Girdin regulates basal body positioning
"A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis."
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NPHP-4 used as marker for basal body region
"A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis."
Deep research report on nphp-4