Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniPathway vocabulary mapping

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry P27544 (CERS1_HUMAN), ceramide synthase 1

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells.

Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast.

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.

(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length.

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.

Impairment of ceramide synthesis causes a novel progressive myoclonus epilepsy.

Eleven residues determine the acyl chain specificity of ceramide synthases.

De novo sphingolipid biosynthesis necessitates detoxification in cancer cells.

Sphingolipid de novo biosynthesis

Ceramide synthases transfer acyl-CoA onto sphingoid