Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage.
DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53.
A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression.
Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis.
Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase.
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1.
Aprataxin, a novel protein that protects against genotoxic stress.
The FHA domain of aprataxin interacts with the C-terminal region of XRCC1.
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation.
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.
No death without life: vital functions of apoptotic effectors.
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Purification of proteins associated with specific genomic Loci.
A role of DNA-PK for the metabolic gene regulation in response to insulin.
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications.
PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.
Defining the membrane proteome of NK cells.
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.
The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.
hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress.
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.
Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks.
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.
Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein.
BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.
Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
ZNF365 promotes stalled replication forks recovery to maintain genome stability.
PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation.
Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair.
PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.
Family-wide analysis of poly(ADP-ribose) polymerase activity.
Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene.
Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function.
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Systematic identification of molecular links between core and candidate genes in breast cancer.
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.
Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.
HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.
ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.
Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
Serine ADP-Ribosylation Depends on HPF1.
Architecture of the human interactome defines protein communities and disease networks.
Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.
Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.
Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.
PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.
Interplay of Histone Marks with Serine ADP-Ribosylation.
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.
KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells.
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome.
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Structural basis for allosteric PARP-1 retention on DNA breaks.
Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy.
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response.
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis.
An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation.
CARM1 regulates replication fork speed and stress response by stimulating PARP1.
HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage.
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair.
Serine-linked PARP1 auto-modification controls PARP inhibitor response.
The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.
Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.
SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage.
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage.
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.
Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.
Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage.
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins.
Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.
Irreversible binding of poly(ADP)ribose polymerase cleavage product to DNA ends revealed by atomic force microscopy: possible role in apoptosis.
Downregulation of SMAD2/3:SMAD4 transcriptional activity
PARP1 ADP-ribosylates SMAD3 and SMAD4
PARP1 binds SMAD2/3:SMAD4 heterotrimer
PIAS4 SUMOylates PARP1 with SUMO1
PIAS4 SUMOylates PARP1 with SUMO2,3
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
POLB-mediated DNA strand displacement synthesis
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB
PARG dePARylates PARP1,PARP2
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
POLQ extends annealed 3'-ssDNA overhangs in MMEJ
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
Formation of the pre-incision complex in GG-NER
Recruitment of XPA and release of CAK
DNA polymerases delta, epsilon or kappa bind the GG-NER site
3'-incision of DNA by ERCC5 (XPG) in GG-NER
5'- incision of DNA by ERCC1:ERCC4 in GG-NER
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
TFIIH binds GG-NER site to form a verification complex
PARP1 or PARP2 PARylates DDB2 and autoPARylates
PARP1 or PARP2 binds DDB2 at GG-NER site
CHD1L is recruited to GG-NER site
RNF111 ubiquitinates SUMOylated XPC
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
Poly(ADP-ribose) (PAR) polymer is a death signal.
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).