Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.

SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

A reference map of the human binary protein interactome.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability.

Multimodal cell maps as a foundation for structural and functional genomics.

Mutations of the SLX4 gene in Fanconi anemia.

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.

XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4.

Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.

The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.

SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)

Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)

DNA nucleases bind monoubiquitinated ID2 complex

DNA nucleases unhook the interstrand crosslink (ICL)