Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10029623

Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis.

FTCD is a liver-specific cytosolic autoantigen recognized by anti-liver cytosol type 1 autoantibodies in autoimmune hepatitis, present as a ~240 kDa oligomer.

PMID:12815595

The molecular basis of glutamate formiminotransferase deficiency.

Missense variants R135C and R299P reduce glutamate formimidoyltransferase activity to 61% and 57% of wild-type, establishing FTCD's catalytic function and its role in glutamate formiminotransferase deficiency (FIGLU-uria).

PMID:14697341

Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis.

Human FTCD is present free in the cytosol and associated with Golgi membranes (reversible binding); the human protein does not interact with cytoskeleton proteins, unlike rat FTCD which binds brain microtubules and vimentin.

PMID:19056867

Large-scale proteomics and phosphoproteomics of urinary exosomes.

FTCD was among 1132 proteins identified by LC-MS/MS in human urinary exosomes; a bulk proteomic detection rather than evidence of functional extracellular localization.

PMID:25416956

A proteome-scale map of the human interactome network.

Systematic binary interactome (Y2H) screen; source of high-throughput protein-binding IPI annotations for FTCD with no gene-specific functional follow-up.

PMID:32296183

A reference map of the human binary protein interactome.

HuRI systematic binary interactome map; source of high-throughput protein-binding IPI annotations for FTCD with no gene-specific functional follow-up.

Reactome:R-HSA-70920

N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

Cytosolic FTCD catalyzes N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate; the octameric human enzyme is inferred by homology to the porcine protein.