trr1 (SPBC3F6.03, synonym caf4, UniProt Q92375) – notes

Low-Mr (class-II) thioredoxin reductase. Module: thioredoxin reductase in glutathione_thioredoxin_redox_systems. S. cerevisiae orthologs TRR1 (cytosolic, review genes/yeast/TRR1) and TRR2 (mitochondrial).

Naming trap: synonym caf4 collides with unrelated S. cerevisiae CAF4 (CCR4-associated factor).

Evidence

• Only TrxR gene: PMID:15135546
• Activity by dosage: PMID:15135546
• Pap1-mediated induction by menadione/HgCl2 PMID:15135546.
• IDA + IPI (with Tpx1) from PMID:17409354, abstract-only; abstract does not mention Trr1. Deferred to curator for IDA; IPI "protein binding" removed per policy.
• Cytosol/nucleus ORFeome HDA PMID:16823372. Mitochondrion ISS from S. cerevisiae TRR2 left UNDECIDED: plausible (single TrxR, mitochondrial Trx2 exists) but no S. pombe data.

Decisions

• removal of superoxide radicals (InterPro2GO IPR005982) REMOVE, as in yeast TRR1.
• Core MF GO:0004791, BP GO:0045454, cytosol — matches yeast TRR1.
• No PomBase GO-CAM association for trr1 in the module (only YeastPathways THIOREDOX-PWY for TRR1/TRR2).