Annotation inferences using phylogenetic trees

An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicans.

CSH3 is a functional and structural homolog of S. cerevisiae Shr3p.

"The Candida albicans CSH3 gene encodes a functional and structural homologue of Shr3p, a yeast protein that is specifically required for proper uptake and sensing of extracellular amino acids in Saccharomyces cerevisiae."
csh3-delta mutant has reduced amino acid uptake and impaired morphological switching.

"A Candida csh3delta/csh3delta null mutant has a reduced capacity to take up amino acids, and is unable to switch morphologies on solid and in liquid media in response to inducing amino acids."
CSH3 haploinsufficiency affects virulence in mouse model.

"both CSH3/csh3delta heterozygous and csh3delta/csh3delta homozygous strains are unable to efficiently mount virulent infections in a mouse model."

Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control.

PMID:19824013

Analysis of Candida albicans plasma membrane proteome.

file:CANAL/CSH3/CSH3-deep-research-falcon.md

Deep research report on CSH3 (Falcon/Edison Scientific Literature)

CSH3 is a Candida albicans Shr3-family ER membrane packaging/folding chaperone that enables amino acid permease biogenesis and ER exit; the evidence supports ER membrane localization, not a cell-surface or adhesin role.