Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Combined Automated Annotation using Multiple IEA Methods

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels.

Overexpression of Osmosensitive Ca(2+)-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells.

Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration.

TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.

Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion.

Phospholipid scrambling induced by an ion channel/metabolite transporter complex.

Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution.

Membrane structure-responsive lipid scramblase activity of the TMEM63/OSCA family.

Structural and functional basis of mechanosensitive TMEM63 channelopathies.

TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience.

Autoinhibition of the mechanosensitive lipid scramblase TMEM63B by its C-terminal tail.

A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function.