Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on the manual curation of subcellular localization
Electronic GO annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.
Towards a proteome-scale map of the human protein-protein interaction network.
SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis.
Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT.
Defining the human deubiquitinating enzyme interaction landscape.
Next-generation sequencing to generate interactome datasets.
Toward an understanding of the protein interaction network of the human liver.
SGTA antagonizes BAG6-mediated protein triage.
SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
A proteome-scale map of the human interactome network.
Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Widespread macromolecular interaction perturbations in human genetic disorders.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
A proteome-scale map of the SARS-CoV-2-human contactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Cytosolic quality control / TA-protein targeting pathway
Cytosolic quality control / TA-protein targeting pathway
UniProt entry O43765 (SGTA_HUMAN), small glutamine-rich TPR-containing protein alpha
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SGTA is a cytosolic homodimeric TPR co-chaperone that binds HSC70/HSP70/HSP90 and hydrophobic clients, mediates tail-anchored protein targeting to the ER via the BAG6/ASNA1 (GET) pathway, and antagonizes BAG6-mediated ubiquitination to bias clients toward maturation over degradation. Cytoplasmic and nuclear.
Falcon deep research report for SGTA
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SGTA is a cytosolic TPR co-chaperone whose TPR domain receives hydrophobic clients from Hsp70 (recognizing the C-terminal EEVD motif of Hsp70/Hsp90), captures tail-anchored membrane proteins via its C-terminal helical-hand domain, and acts as an uncommitted client holder that triages clients between TRC40-mediated ER targeting and BAG6-mediated ubiquitination/degradation; SGTA can antagonize the degradation pathway and (with USP5) promote deubiquitination of mislocalized proteins.