Gene Ontology annotation based on Enzyme Commission mapping

Annotation inferences using phylogenetic trees

Electronic Gene Ontology annotations created by ARBA machine learning models

Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells.

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.

The Drosophila caspase DRONC is regulated by DIAP1.

An essential role for the caspase dronc in developmentally programmed cell death in Drosophila.

Characterization of the Drosophila caspase, DAMM.

The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway.

Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily.

Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.

Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1.

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination.

Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization.

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.

A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration.

Role of programmed cell death in patterning the Drosophila antennal arista.

Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development.

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.

Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.

Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila.

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis.

A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila.

DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.

The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.

Inactivation of effector caspases through nondegradative polyubiquitylation.

Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development.

Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc.

Differential localization and processing of apoptotic proteins in Malpighian tubules of Drosophila during metamorphosis.

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

NOPO modulates Egr-induced JNK-independent cell death in Drosophila.

Comprehensively surveying structure and function of RING domains from Drosophila melanogaster.

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

Anent the genomics of spermatogenesis in Drosophila melanogaster.

Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting.

Cellular inhibitor of apoptosis protein 1 ubiquitinates endonuclease G but does not affect endonuclease G-mediated cell death.

Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.

Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies.

Phosphorylated HPO dimer phosphorylates TH