Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.

ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Insights into Lysosomal PI(3,5)P(2) Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Synthesis of PIPs at the early endosome membrane

Synthesis of PIPs at the late endosome membrane

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane

PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the early endosome membrane

PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the late endosome membrane

PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane

PI is phosphorylated to PI5P by Pikfyve at the late endosome membrane

The DNA sequence and analysis of human chromosome 6.

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.

Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.

Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.

Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P₂ phosphatase FIG4.

Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase.

Role of the phosphoinositide phosphatase FIG4 gene in familial epilepsy with polymicrogyria.

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells.

UniProtKB Q92562 reviewed human FIG4 record

PTHR45738 original PAINT IBD assertions selected using the complete family topology

FIG4 source evidence and assay boundaries