Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.

Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus.

Casein kinase 1 regulates connexin-43 gap junction assembly.

Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.

Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.

Towards a proteome-scale map of the human protein-protein interaction network.

Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1.

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.

Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.

Isoform specific phosphorylation of p53 by protein kinase CK1.

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).

The Hippo pathway regulates Wnt/beta-catenin signaling.

Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity.

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.

Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.

Casein kinase iδ mutations in familial migraine and advanced sleep phase.

Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.

A proteome-scale map of the human interactome network.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.

A reference map of the human binary protein interactome.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

A central chaperone-like role for 14-3-3 proteins in human cells.

Multimodal cell maps as a foundation for structural and functional genomics.

Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.

COPII-mediated vesicle transport

AJUBA facilitates AURKA autophosphorylation

AJUBA binds centrosome-associated AURKA

AURKA phosphorylates PLK1

BORA binds PLK1 and AURKA

Plk1-mediated phosphorylation of Nlp

Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome

Loss of C-Nap-1 from centrosomes

Dissociation of Phospho-Nlp from the centrosome

Recruitment of Plk1 to centrosomes

Association of NuMA with microtubules

Recruitment of CDK11p58 to the centrosomes

Translocation of NuMA to the centrosomes

RAB3IP stimulates nucleotide exchange on RAB8A

C2CD3 binds the mother centriole

C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

CP110 and CEP97 dissociate from the centriole

The distal appendage proteins recruit TTBK2

Recruitment of transition zone proteins

MARK4 binds ODF2 in the centriole

CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

CSNK1D phosphorylates SEC23

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol

TPX2 binds AURKA at centrosomes

TPX2 promotes AURKA autophosphorylation