FZD10 notes

Deep research

just deep-research-falcon human FZD10 --fallback perplexity-lite failed (falcon/perplexity
providers unavailable in this environment, 2026-10-21). Research below is from the cached
publications and the UniProt record.

Frizzled-10 (CD350), class F GPCR, 581 aa. "human FZD10 gene encodes a seven-transmembrane-receptor of
581 amino acids, with the N-terminal cysteine-rich domain and the C-terminal Ser/Thr-Xxx-Val motif"
PMID:10448064. Signal peptide 1-20, extracellular CRD (21-225), 7 TM helices; three N-glycosylation
sites in UniProt [file:human/FZD10/FZD10-uniprot.txt].
FZD9/FZD10 subfamily: "FZD10 and FZD9 constitute a subfamily among the Frizzled genes" PMID:10448064.

Cell surface, ECD exposed: an anti-ECD antibody mediated ADCC on synovial sarcoma cells
PMID:16007199;
"MAb 92‐13 bound to cell surfaces of four FZD10‐overexpressing synovial sarcoma cell lines" and is
internalized after binding PMID:18271942.
Conclusion: plasma membrane, extracellular CRD exposed at the cell surface; internalizes on antibody binding.
Cytoplasm IDA (PMID:16007199) is from IHC of tumors (abstract-only); not verifiable here.

Wnt receptor: in FZD-knockout rescue, "Wnt9b induced canonical signaling with FZD5 and FZD8, but also with
FZD4 and FZD10" and "Wnt9a signaled only via FZD4 and FZD10" PMID:28733458.
Non-canonical: overexpression in synovial sarcoma activates Dvl2/3 phosphorylation and Rac1-JNK,
lamellipodia PMID:19137009.
HIG2/HILPDA binds the FZD10 ECD and enhances Wnt signaling PMID:15930302; myocilin binds Frizzled CRDs
PMID:19188438.
PDZ-binding C-terminal motif binds many PDZ proteins in holdup assays PMID:36115835.

ISS rows for neuron differentiation and cellular response to retinoic acid have WITH = UniProtKB:P56706,
which is human WNT7B (a ligand, not a homolog); sequence-similarity transfer from it is invalid.
IBA extracellular region comes from the sFRP node PTN002259328 (see PTHR11309 family review); FZD10 is a
7TM protein, not secreted.