Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases.
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The 22 mtDNA-encoded tRNAs are used by the mitochondrial protein synthesis machinery to translate the 13 mtDNA-encoded mRNAs.
"These mRNAs are translated by the mitochondrial protein synthesis machinery, which uses the 22 species of mitochondrial tRNAs (mt tRNAs) encoded by mtDNA."
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mt tRNA genes are frequent sites of pathogenic point mutations.
"The genes encoding mt tRNAs are highly susceptible to point mutations, which are a primary cause of mitochondrial dysfunction and are associated with a wide range of pathologies."