Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Identification of human placental leucine aminopeptidase as oxytocinase.
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Purified human P-LAP (LNPEP) hydrolyzes oxytocin, vasopressin and angiotensin III.
"the enzyme hydrolyzed oxytocin, vasopressin, and angiotensin III"
Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase.
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The AT4 receptor binding site is IRAP (LNPEP).
"we identify the AT(4) receptor, by protein purification and peptide sequencing, to be insulin-regulated aminopeptidase (IRAP)"
Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides.
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P-LAP (LNPEP) translocates from intracellular vesicles to the plasma membrane in PC12 cells and degrades the neuropeptides Met-enkephalin and dynorphin A (1-8).
"P-LAP was shown to degrade several bioactive neuropeptides such as Met-enkephalin and dynorphin A (1-8)"
Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking.
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In human adipocytes IRAP (LNPEP) is in GLUT4-containing membrane vesicles and translocates to the plasma membrane in response to insulin.
"IRAP is expressed and translocates to PM in response to insulin"
UniProtKB Swiss-Prot record Q9UIQ6 (human LNPEP), fetched 2026-10-14
LNPEP: donkey-human sequence comparison
UniProtKB record A0A9L0JGC2 (donkey LNPEP)