ATF5 notes

Deep research: not run (falcon times out after 600 s in this environment and perplexity-lite is not installed). Review based on cached publications, UniProt, Reactome and PubMed lookups.

• Mammalian UPRmt transcription factor, functional counterpart of C. elegans ATFS-1 PMID:27426517
• Required for stress-induced HSP60/mtHSP70/LONP1 transcription PMID:27426517
• Reactome curates ATF5 + HSF1 at HSPD1/HSPE1 and HSPA9 promoters [Reactome:R-HSA-9857071].
• Other targets: BCL2 PMID:21212266, CHOP via AARE1 PMID:20654631; C/EBPB cofactor in adipogenesis PMID:24216764; centrosomal PCM ring PMID:26213385.
• GOA lacked GO:0034514; added as NEW (IMP, PMID:27426517). Comparator: worm ATFS-1 carries GO:0034514.
• bZIP partner IPIs (CEBPA, CEBPG) modified to protein heterodimerization activity; other protein binding removed.