Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.
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RFXANK is the third subunit of the RFX complex
"the identification of RFXANK, the gene encoding a third subunit of RFX"
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RFXANK contains ankyrin repeats (protein-protein interaction domains)
"RFXANK contains a protein-protein interaction region consisting of three ankyrin repeats"
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RFXANK interaction with RFX5 and RFXAP is essential for RFX complex binding to MHC-II promoters
"Its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters"
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RFXANK mutations cause MHC class II deficiency (complementation group B)
"RFXANK restores MHC-II expression in cell lines from patients in group B and is mutated in these patients"
Associations and interactions between bare lymphocyte syndrome factors.
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The heterotrimeric RFX complex consists of RFX-B (RFXANK), RFX5, and RFXAP
"The bare lymphocyte syndrome, a severe combined immunodeficiency due to loss of major histocompatibility complex (MHC) class II gene expression, is caused by inherited mutations in the genes encoding the heterotrimeric transcription factor RFX (RFX-B, RFX5, and RFXAP)"
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Ankyrin repeats of RFX-B are necessary for RFX complex formation
"The results identified specific domains within each of the three RFX subunits that were necessary for RFX complex formation, including the ankyrin repeats of RFX-B"
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DNA binding is dependent on RFX complex formation
"DNA binding was dependent on RFX complex formation"
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Transactivation is dependent on a region of RFX5
"transactivation was dependent on a region of RFX5"
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RFX5 interacts with CIITA
"RFX5 was found to interact with CIITA, and this interaction was dependent on a proline-rich domain within RFX5"
An atlas of combinatorial transcriptional regulation in mouse and man.
Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.
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RFX comprises RFX5 (two copies), RFXAP, and RFXB (RFXANK)
"RFX comprises three proteins: RFX5 (two copies), RFXAP, and RFXB"
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RFX5 and RFXAP assemble in cytoplasm prior to nuclear localization
"Two RFX5 molecules and one RFXAP molecule assemble in the cytoplasm prior to nuclear localization"
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The RFX5-RFXAP complex binds RFXB with high affinity
"the RFX5(N)(2)-RFXAP(C) complex binds RFXB with high affinity"
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
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RFXANK ankyrin repeats recognize PxLPxI/L motif in RFX5
"the ankyrin repeat domains of ANKRA2 and its close paralog regulatory factor X-associated ankyrin-containing protein (RFXANK) recognize a PxLPxI/L motif found in diverse binding proteins, including... regulatory factor X, 5 (RFX5)"
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RFXANK also binds HDAC4, HDAC5, HDAC9 via their PxLPxI/L motifs
"the ankyrin repeat domains of ANKRA2 and its close paralog regulatory factor X-associated ankyrin-containing protein (RFXANK) recognize a PxLPxI/L motif found in diverse binding proteins, including HDAC4, HDAC5, HDAC9"
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Disease-causing mutations in RFXANK affect residues critical for RFX5 binding
"three disease-causing mutations in RFXANK affect residues that are critical for binding to RFX5"
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Crystal structure reveals tumbler-lock binding mode
"Crystal structures of the ankyrin repeat domain of ANKRA2 in complex with its binding peptides revealed that each of the middle three ankyrin repeats of ANKRA2 recognizes a residue from the PxLPxI/L motif in a tumbler-lock binding mode"
Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.
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RFXANK interacts with RFX7 via its ankyrin repeats
"ankyrin repeats of ANKRA2 and the paralogous bare lymphocyte syndrome transcription factor RFXANK recognize PxLPxL/I motifs... suggest novel regulatory mechanisms for histone deacetylases and RFX7"
Structural basis for the recognition of RFX7 by ANKRA2 and RFXANK.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.