A redox switch in angiotensinogen modulates angiotensin release.

Structural basis for the specificity of renin-mediated angiotensinogen cleavage.

Angiotensinogen-deficient mice with hypotension.

Cys18-Cys137 disulfide bond in mouse angiotensinogen does not affect AngII-dependent functions in vivo.

Molecular cloning of the mouse angiotensinogen gene.

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans.

Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.

Angiotensin II-induced sudden arrhythmic death and electrical remodeling.

Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system.

Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster.

Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.

Cloning and characterization of a human angiotensin II type 1 receptor.

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.

Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells.

Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages.

Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression.

Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.

Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis.

Novel role of the clustered miR-23b-3p and miR-27b-3p in enhanced expression of fibrosis-associated genes by targeting TGFBR3 in atrial fibroblasts.

Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells.

Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation.

A molecular variant of angiotensinogen associated with preeclampsia.

Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation.

Enzymatic degradation and electrophoresis of human angiotensin I.

The human plasma proteome: a nonredundant list developed by combination of four separate sources.

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

Affinage mechanistic annotation for AGT (human)

UniProtKB P01019 (ANGT_HUMAN) flat file

AGT (P01019) - bioinformatics support for the annotation review

Annotation inferences using phylogenetic trees

Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Combined Automated Annotation using Multiple IEA Methods

Expression of AGT

Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))

Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))

Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))

MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)

ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))

ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))

Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))

ACE:Zn2+ hydrolyzes AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7))

ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8))

ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))

Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

AGT(25-32) binds to AGTR1

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Liganded Gi-activating GPCR acts as a GEF for Gi

Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

The Ligand:GPCR:Gq complex dissociates

The Ligand:GPCR:Gi complex dissociates

Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

AGT(25-32) binds to AGTR2

AGT(25-31) is decarboxylated to yield Alamandine

AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)

ANPEP hydrolyzes Angiotensin III to Angiotensin IV