Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation.

PMID:17897319

Integral and associated lysosomal membrane proteins.

PMID:18256511

Human RME-8 is involved in membrane trafficking through early endosomes.

DNAJC13/RME-8 is a peripheral membrane protein associated via its N-terminal region, colocalizing with early but not late endosomal markers; C-terminal truncation compromises transferrin recycling and EGF/EGFR degradation.

PMID:18307993

RME-8 regulates trafficking of the epidermal growth factor receptor.

RME-8 depletion decreases EGFR via increased degradation, implicating RME-8 in endosomal sorting decisions affecting EGFR.

PMID:19056867

Large-scale proteomics and phosphoproteomics of urinary exosomes.

PMID:19946888

Defining the membrane proteome of NK cells.

PMID:24643499

RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.

FAM21 (WASHC2) binds the SNX1-interacting DNAJ protein RME-8; loss of RME-8 alters SNX1 membrane-association kinetics and causes excessive branched endosomal tubules.

PMID:28514442

Architecture of the human interactome defines protein communities and disease networks.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Reactome:R-HSA-6798739

Neutrophil degranulation (azurophil granule)

Reactome:R-HSA-6798743

Neutrophil degranulation (secretory granule / plasma membrane)

file:human/DNAJC13/DNAJC13-uniprot.txt

UniProt entry O75165 (DJC13_HUMAN), DnaJ homolog subfamily C member 13 / RME-8

Involved in membrane trafficking through early endosomes (transferrin recycling and EGF/EGFR degradation); regulates endosomal membrane tubulation and SNX1 dynamics; binds WASHC2 to link the WASH complex to the retromer SNX-BAR subcomplex; peripheral early-endosome membrane protein with an internal J domain.