file:genes/MYCSM/arr/arr-uniprot.txt

UniProt flat file for arr (O67972)

UniProt identifies this entry as rifampin ADP-ribosyl transferase Arr-1.

"DR CARD; ARO:3002846; arr-1; ARO:0001004; antibiotic inactivation."

Ribosylative inactivation of rifampin by Mycobacterium smegmatis is a principal contributor to its low susceptibility to this antibiotic.

Genetic disruption and biochemical assays identify Arr-mediated rifampin ribosylation as a resistance mechanism.

"Targeted disruption of the gene in M. smegmatis resulted in mutants with much increased susceptibility to rifampin"

file:projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml

Curated ARO to GO mapping set for AMR gene families

The AMR mapping records Arr as a GO molecular-function gap because the nearest ADP-ribosyltransferase terms are wrong for rifampin mono-ADP-ribosylation.

"GO's nearest term GO:0003950 is NAD+ poly-ADP-ribosyltransferase"