Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
UniProt record for donkey ALKAL2 (A0A9L0J5U7)
UniProt Swiss-Prot record for human ALKAL2 (Q6UX46)
ALKAL2: donkey-human sequence comparison
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The donkey protein lacks the human interchain-disulfide cysteine but conserves the augmentor-domain disulfides.
"Human Cys66, the interchain (dimer) disulfide cysteine in the N-terminal variable region, maps to donkey Tyr67"
FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
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The dimerizing cysteine of ALKAL2 is primate-specific and the variable region is dispensable for receptor activation.
"a fifth, primate-specific cysteine located in the N-terminal variable region mediates dimerization"
Structural basis of cytokine-mediated activation of ALK family receptors.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.