Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Adenylyl cyclase G is activated by an intramolecular osmosensor.
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ACG is activated by high osmolality and mediates inhibition of spore germination by this stress factor.
"Adenylyl cyclase G (ACG) is activated by high osmolality and mediates inhibition of spore germination by this stress factor."
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The ACG osmosensor is intramolecular, defining ACG as the first characterized primary osmosensor in eukaryotes.
"This strongly suggests that the ACG osmosensor is intramolecular, which would define ACG as the first characterized primary osmosensor in eukaryotes."
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ACG activity requires dimerization via a region outside the catalytic domain, but dimerization does not mediate osmotic activation.
"This indicates that ACG activity requires dimerization via a region outside the catalytic domain"
Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG.
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Caffeine inhibits cAMP accumulation by ACG as well as by ACA and ACB.
"Caffeine, which was previously used to specifically block ACA function, also inhibited cAMP accumulation by ACB and ACG."
cAMP production by adenylyl cyclase G induces prespore differentiation in Dictyostelium slugs.
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ACG protein is upregulated in prespore tissue and acg null mutants show reduced prespore differentiation, severe when ACB is also deleted.
"acg null mutants show reduced prespore differentiation, which becomes very severe when ACB is also deleted."
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In spores, ACG localizes at the cell periphery as expected for a transmembrane osmosensor.
"In spores, ACG was localized at the cell periphery as would be expected for a transmembrane osmosensor"
From drought sensing to developmental control: evolution of cyclic AMP signaling in social amoebas.
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The osmolyte-activated adenylate cyclase ACG produces cAMP for prespore differentiation and inhibition of spore germination, and this role is conserved across the Dictyostelia.
"The osmolyte-activated adenylate cyclase, ACG, produces cAMP for prespore differentiation and inhibition of spore germination."
The polyketide MPBD initiates the SDF-1 signaling cascade that coordinates terminal differentiation in Dictyostelium.
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SDF-1 acts through ACG to activate PKA and trigger production of more SDF-1.
"SDF-1 apparently acts through the adenylyl cyclase ACG to activate the cyclic AMP (cAMP)-dependent protein kinase A (PKA) and trigger the production of more SDF-1."
Regulation of Dictyostelium adenylylcyclases by morphogen-induced modulation of cytosolic pH or Ca2+ levels.
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ACG activity is optimal at pH 8 and virtually absent below pH 7, and is insensitive to Ca2+.
"basal and GTP gamma S-stimulated ACA activity as well as ACG activity are optimal at pH 8 and are virtually absent below pH 7"
Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores.
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acg null cells form normal fruiting bodies with viable spores, but spore germination is no longer inhibited by high osmolarity.
"acg- cells developed into normal fruiting bodies with viable spores, but spore germination was no longer inhibited by high osmolarity"
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ACG activity is strongly stimulated by high osmolarity, with optimal stimulation at 200 milliosmolar.
"ACG activity, measured in aca-/ACG cells, was strongly stimulated by high osmolarity with optimal stimulation occurring at 200 milliosmolar."
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ACG is an osmosensor controlling spore germination through activation of protein kinase A.
"These data indicate that ACG is an osmosensor controlling spore germination through activation of protein kinase A."
OpenScientist focused acgA GO:0001653 hypothesis report
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Report recommendation was critically incorporated; the disputed molecular/process claim remains UNDECIDED because the report does not resolve the decisive primary evidence.
"no primary study links it to ACG."