Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.
-
fzo-1 is identified as a profusion gene in C. elegans
"profusion genes fzo-1 and eat-3 or the profission gene drp-1 are not required for apoptosis activation in C. elegans"
-
profusion genes fzo-1 and eat-3 are not required for apoptosis activation
"Here we report that profusion genes fzo-1 and eat-3 or the profission gene drp-1 are not required for apoptosis activation in C. elegans."
-
fzo-1 is dispensable for normal apoptotic processes during embryonic development
"Our findings demonstrate that mitochondria dynamics do not regulate apoptosis activation in C. elegans"
Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans.
-
In fzo-1 mutant, mitochondrial fission occurs but fusion is restricted
"in a fzo-1 mutant, in which mitochondrial fission occurs but mitochondrial fusion is restricted"
-
Loss of ced-9 does not affect mitochondrial morphology in fzo-1 mutant
"loss of ced-9 did not affect the mitochondrial morphology observed in a drp-1 mutant, in which mitochondrial fusion occurs but mitochondrial fission is defective, or in a fzo-1 mutant"
-
Confirms fzo-1 role in mitochondrial fusion
"in a fzo-1 mutant, in which mitochondrial fission occurs but mitochondrial fusion is restricted"
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.
-
fzo-1 was used in epistatic analysis of mitochondrial fission
"we knocked down mitochondrial fusion genes (fzo-1 and eat-3) in these backgrounds and determined their epistatic relationship"
-
Study confirms fzo-1 promotes fusion opposite to fission mutants
"moma-1 mutants that were grown on drp-1 RNAi gave rise to mitochondria that were indistinguishable from wild-type animals grown on drp-1 RNAi"
A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans.
-
CED-9 physically interacts with FZO-1
"The BCL2-like protein CED-9 of Caenorhabditis elegans has previously been shown to promote mitochondrial fusion by physically interacting with the mitochondrial fusion protein FZO-1"
-
CED-9 promotes mitochondrial fusion by interacting with FZO-1
"CED-9 of Caenorhabditis elegans has previously been shown to promote mitochondrial fusion by physically interacting with the mitochondrial fusion protein FZO-1"
-
EGL-1 shifts CED-9 from profusion to profission
"EGL-1 converts CED-9 into a mitochondrial receptor for DRP-1, thereby shifting its activity from profusion to profission"
Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1-dependent process.
-
fzo-1 depletion causes fragmented mitochondria and interacts with drp-1
"The depletion of fzo-1 results in the accumulation of fragmented mitochondria in the epidermis of animals grown at 20°C and partially restores some tubular mitochondria in the drp-1 mutant animals"